Luis Garza

What if you could grow a new heart or liver if your first one failed? Our lab is interested if organogenesis can happen again in adults. We use skin as our model system and try to ask basic questions about fundamental biology with translational impact in medicine so that we use in vitro cell culture models, mouse models, and also human interventional clinical trials to gain understanding. We are currently focused on two areas. In the first, we are curious how normal noncoding endogenous dsRNA becomes unmasked and sensed by anti-viral sensors in the context of early wounding to prevent differentiation, maintain stem cells and promote regeneration/hair follicle appendage organogenesis. In the second, we are curious—if we can’t grow a new limb in people yet—can we at least reprogram the skin at the stump site of an amputee to be palmoplantar skin?